| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | FC Cincinnati | 34 | 20 | 9 | 5 | 18 | 69 |
| 2 | Orlando City SC | 34 | 18 | 9 | 7 | 16 | 63 |
| 3 | Columbus Crew | 34 | 16 | 9 | 9 | 21 | 57 |
| 4 | St. Louis City SC | 34 | 17 | 5 | 12 | 17 | 56 |
| 5 | Philadelphia Union | 34 | 15 | 10 | 9 | 16 | 55 |
| 6 | New England Revolution | 34 | 15 | 10 | 9 | 12 | 55 |
| 7 | Seattle Sounders | 34 | 14 | 11 | 9 | 9 | 53 |
| 8 | Los Angeles FC | 34 | 14 | 10 | 10 | 15 | 52 |
| 9 | Houston Dynamo | 34 | 14 | 9 | 11 | 13 | 51 |
| 10 | Atlanta United | 34 | 13 | 12 | 9 | 13 | 51 |
| 11 | Real Salt Lake | 34 | 14 | 8 | 12 | -2 | 50 |
| 12 | Nashville SC | 34 | 13 | 10 | 11 | 7 | 49 |
| 13 | Vancouver Whitecaps | 34 | 12 | 12 | 10 | 7 | 48 |
| 14 | FC Dallas | 34 | 11 | 13 | 10 | 4 | 46 |
| 15 | Sporting Kansas City | 34 | 12 | 8 | 14 | -3 | 44 |
| 16 | San Jose Earthquakes | 34 | 10 | 14 | 10 | -4 | 44 |
| 17 | New York Red Bulls | 34 | 11 | 10 | 13 | -3 | 43 |
| 18 | Portland Timbers | 34 | 11 | 10 | 13 | -12 | 43 |
| 19 | Charlotte FC | 34 | 10 | 13 | 11 | -7 | 43 |
| 20 | CF Montreal | 34 | 12 | 5 | 17 | -16 | 41 |
| 21 | Minnesota United | 34 | 10 | 11 | 13 | -5 | 41 |
| 22 | New York City FC | 34 | 9 | 14 | 11 | -4 | 41 |
| 23 | DC United | 34 | 10 | 10 | 14 | -4 | 40 |
| 24 | Chicago Fire | 34 | 10 | 10 | 14 | -12 | 40 |
| 25 | Austin FC | 34 | 10 | 9 | 15 | -6 | 39 |
| 26 | Los Angeles Galaxy | 34 | 8 | 12 | 14 | -16 | 36 |
| 27 | Inter Miami CF | 34 | 9 | 7 | 18 | -13 | 34 |
| 28 | Colorado Rapids | 34 | 5 | 12 | 17 | -28 | 27 |
| 29 | Toronto FC | 34 | 4 | 10 | 20 | -33 | 22 |
