| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | Louisville City | 17 | 8 | 4 | 5 | 6 | 28 |
| 2 | Charleston Battery | 17 | 5 | 7 | 5 | -2 | 22 |
| 3 | New Mexico United | 17 | 7 | 3 | 7 | -7 | 24 |
| 4 | Detroit City | 17 | 8 | 5 | 4 | 7 | 29 |
| 5 | Colorado Springs | 17 | 5 | 4 | 8 | -4 | 19 |
| 6 | Indy Eleven | 17 | 6 | 5 | 6 | -7 | 23 |
| 7 | Rhode Island FC | 17 | 5 | 7 | 5 | 0 | 22 |
| 8 | Memphis 901 FC | 17 | 6 | 3 | 8 | -2 | 21 |
| 9 | Tampa Bay Rowdies | 17 | 4 | 5 | 8 | -8 | 17 |
| 10 | Las Vegas Lights | 17 | 7 | 4 | 6 | 0 | 25 |
| 11 | Sacramento Republic | 17 | 6 | 5 | 6 | 4 | 23 |
| 12 | North Carolina | 17 | 4 | 3 | 10 | -7 | 15 |
| 13 | Pittsburgh Riverhounds | 17 | 5 | 6 | 6 | 2 | 21 |
| 14 | Orange County SC | 17 | 4 | 5 | 8 | -13 | 17 |
| 15 | Birmingham Legion | 17 | 7 | 4 | 6 | -1 | 25 |
| 16 | Hartford Athletic | 17 | 3 | 4 | 10 | -17 | 13 |
| 17 | Oakland Roots SC | 17 | 6 | 3 | 8 | -11 | 21 |
| 18 | Phoenix Rising | 17 | 4 | 5 | 8 | -11 | 17 |
| 19 | Loudoun United | 17 | 3 | 6 | 8 | -6 | 15 |
| 20 | San Antonio | 17 | 4 | 3 | 10 | -11 | 15 |
| 21 | Tulsa Roughnecks | 17 | 5 | 4 | 8 | -9 | 19 |
| 22 | Monterey Bay FC | 17 | 4 | 3 | 10 | -12 | 15 |
| 23 | El Paso Locomotive | 17 | 5 | 3 | 9 | -10 | 18 |
| 24 | Miami FC | 17 | 0 | 1 | 16 | -37 | 1 |