| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | Philadelphia Union | 16 | 11 | 4 | 1 | 20 | 37 |
| 2 | FC Cincinnati | 16 | 8 | 3 | 5 | 5 | 27 |
| 3 | San Diego FC | 17 | 7 | 5 | 5 | 8 | 26 |
| 4 | Vancouver Whitecaps | 15 | 9 | 4 | 2 | 20 | 31 |
| 5 | New York City FC | 16 | 11 | 0 | 5 | 8 | 33 |
| 6 | Inter Miami CF | 14 | 9 | 3 | 2 | 13 | 30 |
| 7 | Minnesota United | 16 | 7 | 4 | 5 | 6 | 25 |
| 8 | Charlotte FC | 16 | 12 | 1 | 3 | 15 | 37 |
| 9 | Nashville SC | 16 | 11 | 3 | 2 | 22 | 36 |
| 10 | Los Angeles FC | 15 | 9 | 2 | 4 | 15 | 29 |
| 11 | Orlando City SC | 15 | 8 | 3 | 4 | 11 | 27 |
| 12 | Columbus Crew | 16 | 8 | 5 | 3 | 7 | 29 |
| 13 | Chicago Fire | 16 | 6 | 5 | 5 | 0 | 23 |
| 14 | Seattle Sounders | 15 | 8 | 6 | 1 | 16 | 30 |
| 15 | Austin FC | 15 | 6 | 7 | 2 | 3 | 25 |
| 16 | Portland Timbers | 16 | 7 | 6 | 3 | 3 | 27 |
| 17 | New York Red Bulls | 16 | 10 | 3 | 3 | 17 | 33 |
| 18 | Colorado Rapids | 16 | 8 | 3 | 5 | 4 | 27 |
| 19 | San Jose Earthquakes | 16 | 4 | 6 | 6 | 4 | 18 |
| 20 | FC Dallas | 16 | 5 | 3 | 8 | -1 | 18 |
| 21 | Real Salt Lake | 16 | 8 | 1 | 7 | 1 | 25 |
| 22 | Houston Dynamo | 16 | 5 | 3 | 8 | -8 | 18 |
| 23 | New England Revolution | 16 | 4 | 3 | 9 | -5 | 15 |
| 24 | St. Louis City SC | 16 | 4 | 5 | 7 | -5 | 17 |
| 25 | Toronto FC | 16 | 2 | 7 | 7 | -4 | 13 |
| 26 | Sporting Kansas City | 16 | 4 | 4 | 8 | -7 | 16 |
| 27 | CF Montreal | 16 | 2 | 5 | 9 | -19 | 11 |
| 28 | Atlanta United | 16 | 4 | 7 | 5 | 0 | 19 |
| 29 | DC United | 16 | 2 | 7 | 7 | -17 | 13 |
| 30 | Los Angeles Galaxy | 15 | 5 | 2 | 8 | -3 | 17 |