| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | Philadelphia Union | 16 | 8 | 2 | 6 | 3 | 26 |
| 2 | FC Cincinnati | 16 | 10 | 2 | 4 | 3 | 32 |
| 3 | San Diego FC | 15 | 10 | 1 | 4 | 9 | 31 |
| 4 | Vancouver Whitecaps | 16 | 7 | 5 | 4 | 5 | 26 |
| 5 | New York City FC | 16 | 6 | 5 | 5 | 0 | 23 |
| 6 | Inter Miami CF | 16 | 7 | 5 | 4 | 5 | 26 |
| 7 | Minnesota United | 16 | 8 | 6 | 2 | 9 | 30 |
| 8 | Charlotte FC | 16 | 5 | 1 | 10 | -9 | 16 |
| 9 | Nashville SC | 16 | 5 | 2 | 9 | -6 | 17 |
| 10 | Los Angeles FC | 15 | 6 | 6 | 3 | 8 | 24 |
| 11 | Orlando City SC | 16 | 6 | 7 | 3 | 4 | 25 |
| 12 | Columbus Crew | 16 | 5 | 6 | 5 | -5 | 21 |
| 13 | Chicago Fire | 15 | 8 | 1 | 6 | 6 | 25 |
| 14 | Seattle Sounders | 16 | 4 | 4 | 8 | -9 | 16 |
| 15 | Austin FC | 16 | 6 | 1 | 9 | -9 | 19 |
| 16 | Portland Timbers | 16 | 4 | 5 | 7 | -5 | 17 |
| 17 | New York Red Bulls | 16 | 2 | 4 | 10 | -10 | 10 |
| 18 | Colorado Rapids | 16 | 3 | 4 | 9 | -15 | 13 |
| 19 | San Jose Earthquakes | 16 | 6 | 2 | 8 | -5 | 20 |
| 20 | FC Dallas | 15 | 4 | 8 | 3 | -3 | 20 |
| 21 | Real Salt Lake | 15 | 3 | 3 | 9 | -12 | 12 |
| 22 | Houston Dynamo | 16 | 4 | 6 | 6 | -3 | 18 |
| 23 | New England Revolution | 16 | 5 | 5 | 6 | 1 | 20 |
| 24 | St. Louis City SC | 16 | 3 | 2 | 11 | -11 | 11 |
| 25 | Toronto FC | 15 | 3 | 6 | 6 | -3 | 15 |
| 26 | Sporting Kansas City | 16 | 3 | 2 | 11 | -14 | 11 |
| 27 | CF Montreal | 16 | 4 | 4 | 8 | -4 | 16 |
| 28 | Atlanta United | 15 | 1 | 5 | 9 | -20 | 8 |
| 29 | DC United | 16 | 3 | 3 | 10 | -18 | 12 |
| 30 | Los Angeles Galaxy | 16 | 0 | 7 | 9 | -18 | 7 |