| Standings | P | W | D | L | GD | PTS | |
|---|---|---|---|---|---|---|---|
| 1 | Philadelphia Union | 23 | 14 | 4 | 5 | 17 | 46 |
| 2 | FC Cincinnati | 23 | 14 | 3 | 6 | 7 | 45 |
| 3 | Nashville SC | 23 | 13 | 5 | 5 | 16 | 44 |
| 4 | San Diego FC | 23 | 13 | 3 | 7 | 15 | 42 |
| 5 | Vancouver Whitecaps | 22 | 12 | 5 | 5 | 13 | 41 |
| 6 | Columbus Crew | 23 | 11 | 8 | 4 | 6 | 41 |
| 7 | Minnesota United | 23 | 11 | 7 | 5 | 13 | 40 |
| 8 | Inter Miami CF | 20 | 11 | 5 | 4 | 11 | 38 |
| 9 | Los Angeles FC | 20 | 10 | 5 | 5 | 12 | 35 |
| 10 | Orlando City SC | 23 | 9 | 8 | 6 | 10 | 35 |
| 11 | New York City FC | 22 | 10 | 4 | 8 | 4 | 34 |
| 12 | Seattle Sounders | 22 | 9 | 7 | 6 | 3 | 34 |
| 13 | New York Red Bulls | 23 | 9 | 6 | 8 | 8 | 33 |
| 14 | Portland Timbers | 22 | 9 | 6 | 7 | 0 | 33 |
| 15 | Charlotte FC | 23 | 10 | 2 | 11 | 1 | 32 |
| 16 | Colorado Rapids | 24 | 8 | 6 | 10 | -6 | 30 |
| 17 | Austin FC | 22 | 8 | 6 | 8 | -7 | 30 |
| 18 | Chicago Fire | 22 | 8 | 5 | 9 | 2 | 29 |
| 19 | San Jose Earthquakes | 23 | 7 | 8 | 8 | 5 | 29 |
| 20 | Real Salt Lake | 22 | 8 | 4 | 10 | -4 | 28 |
| 21 | Houston Dynamo | 23 | 7 | 5 | 11 | -9 | 26 |
| 22 | New England Revolution | 22 | 6 | 7 | 9 | -1 | 25 |
| 23 | Sporting Kansas City | 22 | 6 | 5 | 11 | -6 | 23 |
| 24 | FC Dallas | 22 | 5 | 7 | 10 | -12 | 22 |
| 25 | Toronto FC | 22 | 5 | 6 | 11 | -4 | 21 |
| 26 | Atlanta United | 22 | 4 | 8 | 10 | -15 | 20 |
| 27 | DC United | 23 | 4 | 7 | 12 | -24 | 19 |
| 28 | St. Louis City SC | 22 | 4 | 6 | 12 | -12 | 18 |
| 29 | Los Angeles Galaxy | 23 | 3 | 6 | 14 | -20 | 15 |
| 30 | CF Montreal | 23 | 3 | 6 | 14 | -23 | 15 |
